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Fetal Cells and Fetal DNA in Maternal Blood New Developments for a New Millennium by Sinuhe Hahn

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Published by Karger .
Written in English


  • Materno-fetal medicine,
  • Heredity,
  • Obstetrical Diagnostic Procedures,
  • Medical,
  • Medical / Nursing,
  • Perinatology & Neonatology,
  • Medical / Gynecology & Obstetrics,
  • Gynecology & Obstetrics,
  • Life Sciences - Genetics & Genomics

Book details:

The Physical Object
Number of Pages137
ID Numbers
Open LibraryOL12931280M
ISBN 103805572220
ISBN 109783805572224

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  Although the mother's immune system typically removes unchanged fetal cells from the blood after pregnancy, the ones that have already integrated with maternal tissues escape detection and can. 1. Clin Genet. Feb;59(2) Fetal cells in maternal blood. Wachtel SS(1), Shulman LP, Sammons D. Author information: (1)Department of Obstetrics and Gynecology, University of Tennessee, Jefferson Avenue, Memphis, TN , USA. [email protected] Fetal lymphocytes, trophoblasts, and nucleated red blood cells have each been separated from Cited by:   Initial efforts targeting isolation and analysis of circulating fetal cells in the maternal bloodstream have not proven successful, because of the challenges in detecting sufficient fetal cell numbers in circulation. 4, 5, 6 By contrast, analysis of cell-free DNA (cfDNA) in maternal circulation has shown promise for evaluation of fetal by: Of special relevance to this review, fetal nucleated cells have been demonstrated in maternal circulation (1, 2) and have been widely pursued as potential substrates for noninvasive prenatal diagnosis (3). However, the rarity of such fetal cells in maternal blood has been a major obstacle to the routine application of this concept.

Cell-free fetal DNA (cffDNA) is fetal DNA that circulates freely in the maternal al blood is sampled by is of cffDNA is a method of non-invasive prenatal diagnosis frequently ordered for pregnant women of advanced maternal hours after delivery, cffDNA is no longer detectable in maternal blood. Find helpful customer reviews and review ratings for Fetal Cells and Fetal DNA in Maternal Blood: New Developments for a New Millennium 11th Fetal Cell Workshop, Basel, April Proceedings at Read honest and unbiased product reviews from our users.5/5.   Although certain fetal cells (specifically nucleated red blood cells) have a relatively short lifespan in maternal blood (Lurie and Mamet, ), other fetal cell types can persist in the maternal circulation for decades following pregnancy (Bianchi et al., ), potentially causing false-positive results in subsequent by: Definitive evidence that fetal cells circulate in maternal blood came in when lymphocytes carrying an X and a Y chromosome were detected in the peripheral blood of pregnant women carrying male fetuses. 11 More compelling evidence of the existence of fetal cells in maternal blood came in the s with the development of modern and Cited by:

Test description Blood group genotyping of fetal DNA is performed to predict the blood group antigen status of the fetus at high risk for Hemolytic Disease of the Fetus and Newborn (HDFN). Because cell-free fetal DNA is normally present in maternal blood plasma throughout pregnancy, a non-invasive venipuncture sample can be collected from the mother for testing without risk to . Fatima A. Merchant, Kenneth R. Castleman, in The Essential Guide to Image Processing, Fetal Cell Screening in Maternal Blood. Scientists have documented the presence of a few fetal cells in maternal blood and have envisioned using them to enable noninvasive prenatal screening. Using fetal cells isolated from maternal peripheral blood samples eliminates the . Request PDF | Fetal cells in maternal blood | Fetal lymphocytes, trophoblasts, and nucleated red blood cells have each been separated from maternal blood by methods such as flow cytometry.   It is likely that earlier studies (i.e. Thomas et al., ) demonstrating % Y-sequence detection using maternal whole blood between 4 and 7 weeks were actually measuring cell-free fetal DNA and not intact cells. Although there appears to be considerable variability among subjects in the quantity and timing of fetal DNA's initial presence in Cited by: